Although we could include volumes of information on each unique individual ingredient included in the Doctor’s Beyond Resveratrol® cream, at this point in time we are proud to share educational information on the remarkable resveratrol. Educated consumers make better decisions.
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Information contained on our website is for educational purposes only and is not intended to diagnose, treat, cure or prevent any disease. This information has not been evaluated by the Food and Drug Administration (FDA). No claims and no systemic medical claims are made nor implied for the use of this product.
Doctor’s Beyond Resveratrol® cream was formulated by United States patent holder Dr. Charles Mesko to go “beyond” existing skincare products. Our loyal customers consider Doctor’s Beyond Resveratrol® cream to be the finest skin care product available. Extremely pleased women report that this single product eliminated the need for using one or more expensive over-the-counter skin care products including: moisturizers, eye puffiness creams, wrinkle creams, age-spot creams, skin tightening creams, fine line creams and deep wrinkle creams.
Doctor’s Beyond Resveratrol® cream is considered by natural doctors and our satisfied customers to be a very effective product. Our skin care product is formulated to go “beyond” existing expensive skin care cosmetics and costly over-the-counter skin products to offer skin support to sun damaged, prematurely aged, wrinkled, or malnourished skin on the face, neck and body. It is estimated that 80% of skin damage is caused by the sun.
Originally prompted by the “French Paradox”, the study of resveratrol is the subject of ongoing worldwide clinical research. The French paradox is the observation that the French suffer a relatively low incidence of coronary heart disease, despite having a diet relatively rich in saturated fats. The phenomenon was first noted by Irish physician Samuel Black in 1819. When a description of this paradox was aired in the United States on 60 Minutes in 1991 with the proposal that red wine decreases the incidence of cardiac diseases, the consumption of red wine increased 44%. In 2002, the average French person consumed 108 grams per day of fat from animal sources while the average American consumed only 72. The French eat four times more butter, 60 percent more cheese and nearly three times more pork. Although the French consume only slightly more total fat, they consume much more saturated fat because Americans consume a much larger proportion of fat in the form of vegetable oil, with most of that being soybean oil. According to data from the British Heart foundation, rates of death in 1999 from coronary heart disease among males aged 35–74 years was 115 per 100,000 people in the U.S. but only 83 per 100,000 in France.
Resveratrol is a phytoalexin (or antibiotic) produced naturally by plants when under attack by pathogens such as bacteria or fungi. It is usually sold as a dietary supplement, but is best known as an element contained in red wine. In grapes, resveratrol is found primarily in the skin and in the seeds. The amount found in grape skins also varies with the type of grape, its geographic origin, and exposure to fungal infection. The amount of fermentation time a wine spends in contact with grape skins is an important determinant of its resveratrol content. In experiments on mice and rats, anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects of resveratrol have been reported.
The groups of Howitz and Sinclair reported in 2003 in the journal Nature that resveratrol significantly extended the lifespan of the yeastSaccharomyces cerevisiae. Later studies conducted by Sinclair showed that resveratrol also prolonged the lifespan of the wormCaenorhabditis elegans and the fruit fly Drosophila melanogaster. In 2006, Italian scientists obtained the first positive result of resveratrol supplementation in a vertebrate. Using a short-lived fish with a median life span of nine weeks, they found that resveratrol increased the median lifespan by 56%. Compared with the control fish at nine weeks, the resveratrol-supplemented fish showed significantly higher general swimming activity and better learning to avoid an unpleasant stimulus.
Sinclair later reported that resveratrol counteracted the detrimental effects of a high-fat diet in mice. The high fat diet (from adding hydrogenated coconut oil to the standard diet), provided 60% of energy from fat, and the mice on it consumed about 30% more calories than the mice on the standard diet. Both the mice fed the standard diet and the high-fat diet plus resveratrol had a 30% lower risk of death than the mice on the high-fat diet. Insulin and glucose levels in mice on the high-fat resveratrol diet were closer to the mice on standard diet than the high-fat mice. Adding resveratrol to the diet of mice inhibit muscle aging and age-related cardiac dysfunction. In 2008, a study found that high doses of resveratrol (a constituent of red wine) mimicked some of the benefits of caloric restriction (including reduced effects of aging) in mice.
The study supported Sinclair's hypothesis that the effects of resveratrol are due to the activation of the Sirtuin 1 gene (or SIRT1). Responsible for cellular regulation, sirtuins regulate important biological pathways. They influence aging, stress resistance, assisting in the repair of DNA, and regulating genes that undergo altered expression with age. In a study of 123 Finnish adults, those born with certain increased variations of the SIRT1 gene had faster metabolisms, helping them to burn energy more efficiently—indicating that the same pathway shown in the lab mice works in humans.
In 1997, it was reported that topical resveratrol applications prevented the development of skin cancer in mice treated with a carcinogen. There have since been dozens of studies of the anti-cancer activity of resveratrol in animal models. The whole body effectiveness of resveratrol is limited by its poor systemic bioavailability. Thus, topical application of resveratrol in mice, both before and after UVB exposure, inhibited the skin damage and decreased skin cancer incidence. However, oral resveratrol was ineffective in treating mice inoculated with melanoma cells. In humans, about 70% of resveratrol given as a pill is absorbed; however, it is rapidly metabolized in the intestines and in the liver. Only trace amounts of resveratrol can be detected in the blood after an oral dose. Resveratrol from wine is even less effective: its highest level in the bloodstream is minimal, and it completely disappears after approximately four hours. As evidenced by the mice experiments, topical application is thought to be the most efficient method of delivery. Resveratrol is thought to work at the metabolic level, stimulating the cells’ anti-aging genes through its genetic, metabolic and biochemical mechanisms.