In optimal health, the body's natural production of PEA is in homeostasis. This balance can sometimes be compromised due to negative stimuli. As a result, the response to this threat of imbalance can cause a deficiency in PEA production. Supplementation of PEA works with the body to support this delicate balance, calm discomfort, and promote levels for wellbeing.* In combination with Meriva Curcumin, this formula provides natural support for the entire body with a focus on the body's nervous, immune, and muscular systems.* PURE & NATURAL Enzyme Science offers (PEA)+, a unique blend of PEA, from safflower seed, paired with the well-researched, patented, and highly bioavailable curcumin, Meriva" Phytosome. There are two sources of PEA commercially available. Synthetic forms require the use of powerful synthetic solvents such as toluene. On the other hand, PEA can be naturally derived from safflower lecithin. (PEA)+ only utilizes naturally derived palmitoylethanolamide from safflower seed.(PEA)+ SPEC SHEET Data collected from the 2012 National Health Interview Survey estimated nearly 56% of American adults (126 million individuals) experienced some level of pain or discomfort within 3 months prior to taking the survey.(1) Discomfort can range from a variety of indications, including effects on mood, mobility, and overall health and wellness. Most often, occasional pain, stiffness, and compromised tissue are the result of overexertion and everyday stress. When excited nerves issue sensory information to the brain, the body can react in the form of uncomfortable sensations. Many individuals experiencing common ailments often choose to self-medicate.(2) These consumers turn to easily accessible Over-the-counter medications such as NSAIDs instead of coping with the short term discomfort. A study, led by the Director of the Slone Epidemiology Center at Boston University, evaluating consumer compliance with recommended NSAID usage, found nearly 20% of individuals exceeded daily maximum doses during a one-week period.(3) When misused or overused, these OTCs can have serious side effects. For those experiencing only occasional discomforts, a natural approach may be a better option to support physiological stress.* Dietary supplements work with the body's natural processes for physiological stress and soreness without the side effects associated with the overuse of pain medications.* Palmitoylethanolamide (PEA) is an extensively researched natural ingredient for important neuroprotective actions.*(4) This ingredient has been utilized for decades and is available in dietary supplements worldwide as an option for the onset of physiological stress.* PEA is an endogenous fatty acid amide that belongs to the family of biologically active lipids that are increased by the body to soothe discomfort naturally.*(5) PEA was identified over 60 years ago when it was isolated from extracts of brain, liver, and muscle of rat and guinea pig. It was later found to be contained in chicken egg yolk, olive oil, safflower and soy lecithin, peanut meal, and several other foods.