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Life Extension, AppleWise, Polyphenol Extract, 600 mg - 30 vegetarian capsules

  • $28.99
  • $20.99

The Best But how do you choose the very best nutritional supplements or even know what's in them? Our focus is on quality, purity, potency. Shouldn't that be your focus, too? Our quality control standards actually exceed FDA mandates. We source only the best raw materials for our nutritional supplements. Our products always give you the most nutritional potency for your dollar. We develop science-based supplements you simply won't find anywhere else.

Foundation for Longer Life

  • Apple-A-Day Antioxidant
  • Dietary Supplement

Apple polyphenols are powerful antioxidants. They act as powerful anti-glycation agents and promote a healthy inflammatory response. Apple polyphenols also help support a healthy cardiovascular system, cell division, blood sugar levels already within normal range, and healthy immune function.

Benefits at a Glance:

  • Lowers oxidative stress
  • Supports blood sugar levels already within the normal range
  • Supports cardiovascular health
  • Supports healthy cell division in the colon

Apple Polyphenols May Extend Life by Lowering Oxidative Stress

Apple skins contain many of the polyphenols found in other fruits, but in higher concentrations. One of those compounds is a polyphenol called phloridzin.1-3 Scientists conducting initial investigations found that the use of apple polyphenols increased the life span of various species by 10% to 12% by ramping up gene expression of vital natural cellular antioxidant systems.4-6

Phloridzin Supports Healthy Blood Sugar Levels Already Within Normal Range

The apple polyphenol phloridzin is especially active against glycation, one of the most common causes of normal aging. Phloridzin attacks glycation and its effects at many different levels, starting with blood sugar. Studies show that phloridzin significantly inhibits glucose uptake into intestinal cells, as well as the active transport of glucose out of those cells and into the bloodstream.2-7

Some sugar, of course, is inevitably absorbed, where it forms carbonyl molecules which react with proteins and DNA to form advanced glycation end-products, or AGEs. Phloridzin prevents formation of those carbonyl compounds. Phloridzin also traps any remaining carbonyls that are produced, inhibiting them from reacting with more vulnerable body molecules.3,8,9

Supports Cardiovascular Health

Animal studies show that apple polyphenols slow triglyceride absorption by blocking pancreatic lipase, an enzyme specifically required to break down triglyceride fats.10,11 Blocking pancreatic lipase causes some triglycerides to pass out of the body as waste.12 Additional research has shown that apple polyphenols can increase the protective antioxidant molecule, paraoxonase, by as much as 23%13 to inhibit lipid peroxidation and inflammatory factors.

Supports Healthy Cell Division in the Colon

Apple polyphenols promote colon health by scavenging oxygen free radicals, a potent means of increasing cellular mechanisms and supporting DNA function.14,15 They also enhance production of natural antioxidant enzymes that colon cells use to protect themselves,16-19 inhibit enzymes which produce inflammatory cytokines,20-23 and have been shown to help protect the DNA of colon cells.18,24 Since health conscious people today obtain a wide range of polyphenols (such as green tea and pomegranate extracts), a daily dose of 300 mg to 600 mg of apple polyphenols may be all that is needed to obtain desired benefits.

The benefits of plant polyphenols are well known to health enthusiasts. These natural plant constituents block oxidative damage that leads to inflammation and accelerated biological aging of tissues.

Recent studies by three separate laboratories have concluded that polyphenols extracted from apples extend life span in laboratory models by up to 12%.

Apples and especially their skin, are rich in an array of polyphenols. One particular major bioactive polyphenol, phloridzin, found in the skin of many apple species, has been shown to act as a powerful agent against glycation and other destructive processes in the body. Phloridzin also regulates cell-to-cell signaling and supports healthy glucose levels in those already within normal range by inhibiting the glucose-6-phosphatase enzyme.

Apple polyphenols can slow triglyceride absorption from the intestine by blocking pancreatic lipase, an enzyme specifically required to break down triglyceride fats.

Additional research has shown that apple polyphenols can increase the protective antioxidant molecule, paraoxonase by as much as 23%, thereby inhibiting lipid peroxidation and inflammatory factors.

Along with phloridzin, apples contain chlorogenic acid which supports healthy glucose levels in those already within normal range by inhibiting the glucose-6-phosphatase enzyme, and by increasing some cellular mechanisms that are stimulated by insulin in liver cells.

Suggested Use Take one (1) capsule one to four times daily with or without food, or as recommended by a healthcare practitioner.

Supplement Facts
Serving Size: 1 Vegetarian Capsule
 Amount Per Serving% Daily Value
Apple (Malus domestica) extract (fruit and skin) [std. to 50% polyphenols (300 mg) and 5% phloridzin (30 mg), from organically grown apples]600 mg**
**Daily Value not established

Other Ingredients

Vegetable cellulose (capsule), rice flour, vegetable stearate.

Warnings

Store tightly closed in a cool, dry place.

  • Keep out of reach of children.
  • Do not exceed recommended dose.
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

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