Turmeric Root Extract
Sinatrol includes turmeric standardized to contain 95% curcumin, the yellow plant pigment responsible for the inflammatory balancing actions of turmeric. Curcumin supports a healthy inflammatory response through down-regulation of the activity of cyclooxygenase-2 (COX-2) and lipoxygenase enzymes, as well as interleukin (IL)-1, 2, 6, 8 and 12. Curcumin has also been shown to be a potent antioxidant contributing to balanced inflammatory responses.
Bromelain is a plant enzyme naturally found in the stem and fruit of the pineapple plant. Bromelain exerts a synergistic effect when combined with NAC due to its proteolytic (protein digesting) actions. Bromelain helps to thin nasal secretions with the additional benefit of supporting healthy inflammatory responses. A clinical study conducted in Germany in 2005 found bromelain exhibited statistically significant results for supporting sinus health and soothing sinus tissues.
Berberine sulfate is a botanical extract found in the root and bark of various plants including Oregon grape root and barberry. Berberine extract has been shown to support immune responses. Berberine also supports healthy sinus function.
Licorice Root Extract
Licorice root (Glycyrrhiza glabra) has been used in Eastern and Western cultures for thousands of years. The active components in licorice, glycyrrhizin and glycyrrhetinic acid, provides support for a healthy immune response and inflammatory balance.
Andrographis Leaf Extract
Andrographis paniculata has been used in Eastern medicine for centuries to support the immune system.. In seven double-blind controlled trials, andrographis was found to be a safe and effective botanical for supporting upper respiratory tract health. In a study of 158 patients, a standardized preparation of A. paniculata dried extract administered for five days significantly decreased throat irritations and aided in drying nasal secretions. The active ingredient, andrographolide, has been found to modulate inflammatory response by inhibiting NK-kappa B.
Eleuthero Root Extract
Eleuthero root extract has been shown to support the immune response, especially in combination with andrographis. Two randomized, double-blind, placebo-controlled trials of the combination of Eleuthero and andrographis demonstrated the efficacy of this combination for respiratory challenges. In the initial pilot study, 46 subjects were given the combination three times daily for three to eight days. The second trial included 179 patients treated for three days. In both trials, significant improvement in nasal secretions, throat irritations and general immune response were reported.
Thyme Herb Extract
Thyme has been traditionally used to soothe sinuses and loosen phlegm. Thymol, the active ingredient in thyme, has immune supporting properties and competes with pathogens commonly found in the sinuses and respiratory tract. The German Commission E has approved thyme to support respiratory challenges.