100 x 1000mg Tablets
Panaxea’s Zlim Trim is cutting edge anti-obesity formula that may help attenuate the pathways that lead to weight gain, obesity induced inflammation and altered metabolism. Clinically tested extracts of Forskohlii, Gugglesterones and hydroxycitric acid (from Garcinia) when combined together may help reduce the detrimental health effects of excess abdominal fat and obesity.*
• May support weight loss*
• Increases energy levels*
• May help reduce glucose blood levels*
• Enhances burning of fat tissue and increases caloric expenditure*
• May help reduce obesity induced inflammation*
1. Stohs SJ, Preuss HG, Shara M. A Review of the Human Clinical Studies Involving Citrus aurantium (Bitter Orange) Extract and its Primary Protoalkaloid p-Synephrine. International Journal of Medical Sciences. 2012;9(7):527-538. doi:10.7150/ijms.4446.
Garcinia quaesita contains hydroxycitric acid (HCA)
HCA exerts its anti-obesity effects through its inhibition of the enzyme ATP citrate lyase, playing a critical role in energy storage, and affecting the appetite. Weight gain occurs after the body's capacity for glycogen storage is reached. At this point, glucose from excessive calorie intake is converted into acetyl coenzyme A via a metabolic pathway involving ATP-citrate lyase and then into fat molecules, which are stored in fat cells. HCA inhibits this process by binding to ATP-citrate lyase to reduce the production of acetyl coenzyme A, reducing the body's production of fat and cholesterol. HCA also increases the ability of the liver and muscles to synthesize and store glycogen, thereby suppressing appetite. Early research by Hoffman-La Roche found that HCA interferes with the break-down of fatty acids in the Krebs Cycle resulting in increased energy expenditure, reduced appetite, decreased plasma cholesterol, and inhibited fat synthesis from excess carbohydrate calories (1).*
1. Shara M, Ohia SE, Schmidt RE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D, Stohs SJ. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Mol Cell Biochem. 2004 May;260(1-2):171-86. PubMed PMID: 15228099.
Coleus forskohlii (extract forskolin, standardised to contain '185 forskolin')
Forskolin has been found to decrease fasting blood glucose levels. Previous research found that Forskolin enhanced the glucose-mediated stimulus that induces beta cells to release insulin. This effect was produced by the elevation of cAMP, which activates two main signaling pathways in beta cells. One pathway is mediated by protein kinase A (PKA) and the other is activated by factors of guanine nucleotide exchange that are regulated by cAMP (1).*
1. Ríos-Silva M, Trujillo X, Trujillo-Hernández B, et al. Effect of Chronic Administration of Forskolin on Glycemia and Oxidative Stress in Rats with and without Experimental diabetes. 2014 Mar 11;11(5):448-52. doi: 10.7150/ijms.8034.
E & Z Gugglesterones (Guggul)
Gugglesterones (GS) act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity (1). GS had been demonstrated to suppress lipopolysaccharide-induced inflammation by inhibiting IκB-α degradation and NF-κB activation (2,3). GS has medicinal properties such as anti-inflammatory (4) hepatoprotective (5) and anti-obesity (6).*
1. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, et al. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 2002;296:1703–6
2. Meselhy MR. Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. Phytochemistry. 2003;62:213–8.
3. Shishodia S, Aggarwal BB. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem. 2004;279:47148–58.
4. Francis JA, Raja SN, Nair MG. Bioactive terpenoids and guggulusteroids from Commiphora mukul gum resin of potential anti-inflammatory interest. Chem Biodivers. 2004;1:1842–53.
5. Al-Howiriny TA, Al-Sohaibani MO, Al-Said MS, Al-Yahya MA, El-Tahir KH, Rafatullah S. Hepatoprotective properties of Commiphora opobalsamum (“Balessan”), a traditional medicinal plant of Saudi Arabia. Drugs Exp Clin Res. 2004;30:213–20.
6. Bhatt AD, Dalal DG, Shah SJ, Joshi BA, Gajjar MN, Vaidya RA, et al. Conceptual and methodologic challenges of assessing the short-term efficacy of guggulu in obesity: Data emergent from a naturalistic clinical trial. J Postgrad Med. 1995;41:5.
Tyrosine is a nonessential amino acid. It is generated from one essential amino acid – phenylalanine.
Tyrosine is the immediate precursor to the thyroid hormone thyroxin and melanin. Deficiencies of phenylalanine or tyrosine may result in interruption of the synthesis of melanin or thyroxin. Therapeutic doses of tyrosine may have an impact on thyroid hormone production and basal metabolism.
Tyrosine supplementation has been used in animals to treat elevated and low blood pressure, which illustrates its blood pressure normalizing effects. Tyrosine has also been suggested to be useful for the management of certain nervous system disorders which are associated with low dopamine output such as depression. Therapeutic doses of tyrosine may have an impact upon thyroid hormone product and basal metabolism.