Our Mission For over 30 years, Thorne Research has been dedicated to enhancing the health and well-being of people worldwide by providing innovative, high-quality, research-based nutritional supplements, health diagnostics technology platforms, and the latest in medical education. Through our products and services, our passionate, talented staff, collaboration with a variety of innovative and expert strategic partners, and an unwavering commitment to integrity, Thorne Research strives to become a leading health-care company serving people around the world.
to support estrogen metabolism*
- helps maintain an optimal 2-hydroxy (“good”) to 16-hydroxy (“bad”) estrogen ratio*
- found in cabbage family vegetables
- provides nutritional support for liver detoxification*
- converts to DIM
Indole-3-carbinol (I3C) is a compound found in high concentrations in vegetables of the Brassica family, including broccoli, cauliflower, Brussels sprouts, and cabbage.
As a dietary supplement, I3C provides key nutritional support for liver detoxification.* It also plays an important role in supporting female reproductive health.* The majority of ingested I3C is absorbed in the small intestine as diindolylmethane (DIM), which is thought to be the primary contributor to I3C's beneficial properties. DIM has been shown to selectively bind to estrogen receptors and may act as an estrogen antagonist at physiological concentration.*
In the liver, I3C promotes the metabolism of estrogen and increases the ratio of 2-hydroxy estrogen to 16-hydroxy estrogen.* The 2-hydroxy estrogens, less active than the 16-hydroxy estrogens, generally are eliminated more rapidly from the body. One prospective study found postmenopausal women with the most favorable urinary 2:16-hydroxyestrone ratio were most likely to maintain good female health.*
Preliminary studies have examined the efficacy, safety, and optimal supplementation of I3C. A 12-week phase I trial conducted on 17 women found a 66-percent increase in urinary 2:16-hydroxyestrone ratio with administration of 400 mg I3C daily.*
Suggested Use Take 1 capsule one to two times daily or as recommended by your health-care practitioner.